8 formulas for mindful microdosing
Unique herbal blends
Microdosing Capsules for Focus, Mood & Everyday Balance
Discover a modern approach to wellness with thoughtfully crafted microdose capsules designed to support clarity, emotional balance, and cognitive performance.
At Nuance, we focus on education-first, harm reduction, and intentional use—helping you explore plant-based tools in a grounded, sustainable way.
Nuance offers a premium microdose supplement line built around one foundation — Psilocybe cubensis — and eight distinct formulas designed to help support specific wellness outcomes. Every product is independently lab-tested, vegan, gluten-free, and crafted with transparent, purposeful ingredients. From your first capsule to your most intentional practice.
👉 Explore the full collection below
Lab-tested for potency & purity
Vegan · Gluten-free
GMO-free
Organically grown botanicals
Sustainable practices
Carbon-offset shipping
Certificate of analysis available
Nuance Network Community Included
What Are nuance Microdose Capsules?
Microdosing is the practice of taking small, sub-perceptual amounts of plant-based compounds, in this case P. cubensis mushrooms to support:
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Mental clarity & focus
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Emotional resilience
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Creativity
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Daily balance
Our formulations combine functional mushrooms, adaptogens, and targeted nutrients to create tailored experiences for different needs.​
what you may experience
A gentle lift in mood — subtle emotional warmth without any sense of being altered or impaired
A quiet reduction in stress or mental noise during demanding parts of your day
Increased ease of presence in conversations and everyday moments
A soft sense of calm that supports rather than sedates — balance without heaviness
These effects are sub-perceptual and at the right dose should be able to go about your day as normal but with subtle effect. You should not feel high, or that would be considered above the "sweet spot."
Explore Our Microdose Capsule Collection
neat family - single active ingredient
$24
Beginner · sensitive
The gentlest entry point. 50 mg P. cubensis for first-timers and sensitive individuals. Sub-perceptual calm without compromise.
P. cubensis 50 mg
$35
Most Popular
​The original flagship. Pure P. cubensis at the classic threshold — two ingredients, clean baseline, most recommended formula in the lineup.
P. cubensis 100 mg
$50
Step-up Dose
Double the flagship. For experienced microdosers who found 100 mg too subtle and are ready to step up intentionally.
P. cubensis 200 mg
$98
Advanced · mini-dose
The top of the Neat range. A mini-dose for those with an established psilocybin practice who want to explore the upper boundary.
P. cubensis 500 mg
mindful microdose blends - botanical herbal formulations
$45
Brain health · Stamets Stack
The Stamets Stack in capsule form — psilocybin, Lion's Mane, and Niacin for cognitive support, neurogenesis, and long-term brain health.
P. cubensis 100 mg · Lion's Mane 250 mg · Niacin 20 mg
$45
Nighttime · sleep
Nuance's only nighttime formula. Psilocybin, Skullcap, and pure THC-free CBN — dose at bedtime, integrate while you sleep, wake up restored.
P. cubensis 100 mg · Skullcap 250 mg · CBN 1 mg
$45
Mood · emotional uplift
Mood-forward blend with Albizia — the "collective happiness tree" — and Borage for gentle, plant-based emotional uplift and resilience.
P. cubensis 100 mg · Albizia 250 mg · Borage 100 mg
$45
Energy · physical performance
Psilocybin, Yohimbe, and Ashwagandha for energy, libido, and physical embodiment. Built for the gym, bedroom, and dancefloor.
P. cubensis 100 mg · Yohimbe 250 mg · Ashwagandha 100 mg
Find your formula by goal
I want to start microdosing for the first time
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Start with Neat- 50 mg (sensitive) or Neat 100 mg (standard). Single active ingredient formula, clean baseline, no surprises.
I want better focus and cognitive performance
Try Vitality 100 mg — the Stamets Stack with Lion's Mane and Niacin for neurogenesis and sustained mental clarity.
I want help with sleep and recovery
Try Somnium 100 mg — designed to be taken at bedtime. Skullcap and CBN support deeper, more restful sleep.
I want emotional support and mood uplift
Try Bright 100 mg — Albizia and Borage paired with psilocybin for gentle, sustained mood and emotional resilience.
I want more physical energy and embodiment
Try Dirty 100 mg — Yohimbe and Ashwagandha for physical drive, libido, and energized presence. Daytime formula.
I've been microdosing and want a stronger dose
Step up to Neat+ 200 mg or Neat++ 500 mg depending on your experience and sensitivity.
ingredient glossary
Psilocybe cubensis Mushrooms
(P. cubensis)
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The psilocybin-containing mushroom at the foundation of every Nuance formula. Sub-perceptual at microdose levels — supporting emotional balance, stress relief, and mental openness without any altered perception. Independently lab-tested in every batch for potency and purity.
Lion's Mane Mushrooms
(Hericium erinaceus)
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One of the most well-researched functional mushrooms for brain health. Associated with support for memory, concentration, and nerve growth factor (NGF) — a protein involved in the growth and maintenance of neurons. Sourced from Far West Fungi. The core of the Stamets Stack.
Niacin
(Vitamin B3)
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Acts as a delivery enhancer in the Stamets Stack — supporting increased blood flow and helping transport active compounds throughout the body. May cause a temporary warm, flushed sensation (niacin flush) that is harmless and typically passes within 20–60 minutes.
American Skullcap
(Scutellaria lateriflora)
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A North American native herb with centuries of use as a mild relaxant. Traditionally used to ease nervous tension, anxiety, and restlessness — the calming backbone of the Somnium nighttime formula. Organically grown. Use with caution during pregnancy and breastfeeding.
CBN Isolate
(Cannabinol · 99.8%+ pure)
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A naturally occurring cannabinoid associated with relaxation and sleep support. Non-psychoactive and non-intoxicating — 99.8%+ pure isolate with undetectable THC, independently verified by COA. Adds a notable sedative and calming effect to the Somnium nighttime blend.
Albizia
(Albizia julibrissin)
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Known in traditional Chinese medicine as the "collective happiness tree." Long used to support mood, ease nervous tension, and promote emotional calm — described as a gentle emotional softener. Organically grown. May cause drowsiness; avoid during pregnancy and before surgery.
Borage
(Borago officinalis)
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Rich in gamma-linolenic acid (GLA) and a broad spectrum of antioxidants including flavonoids and phenolic compounds. Long-used traditional botanical for mood and emotional wellbeing support. Organically grown. Avoid if you have liver disease, are pregnant, or have epilepsy.
Yohimbe
(Pausinystalia johimbe)
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Derived from the bark of the Yohimbe tree — one of the most well-known botanicals for supporting arousal, libido, and physical energy. Works by increasing blood flow and enhancing norepinephrine release. Organically grown. May affect blood pressure; consult your doctor if relevant.
Ashwagandha
(Withania somnifera)
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One of Ayurveda's most revered adaptogens. Supports vitality and physical performance by reducing stress and balancing cortisol. Boosts testosterone and overall physical resilience. Organically grown. Use with caution if you have autoimmune conditions or take benzodiazepines.
Cellulose
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Microcrystalline cellulose is a purified, plant-derived fiber used as an inert filler to ensure consistent capsule weight and precise dosing. It also acts as an anti-caking agent and desiccant, helping prevent clumping, control moisture, and maintain product freshness. Additionally, it supports even distribution of active ingredients and is well tolerated by most individuals, making it a reliable component in microdosing formulas.
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Vegan Capsule
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Vegan capsules are plant-based and made without animal-derived ingredients, offering a clean and accessible option for a wide range of dietary needs. They are 100% BSE-free, contain no additives or preservatives, and are gluten-free, Kosher, and Halal certified. Manufactured in a cGMP-compliant facility, these capsules ensure high standards of quality, safety, and consistency in every dose.
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Nuance Network included with every purchase
Your purchase includes access to monthly 60-minute virtual group sessions led by an integration specialist. Third Sunday of each month, 10:00 AM Pacific. Community, education, and peer support — built into the price.
frequently asked questions
What is microdosing?
Microdosing is the practice of taking sub-perceptual doses of a psychedelic compound — typically 5–10% of a recreational dose — on a regular schedule. At these levels the goal is not to feel high, but to experience subtle improvements in mood, focus, emotional resilience, and overall wellbeing. The standard microdose range for dried Psilocybe cubensis is 50–300 mg.
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Which formula should I start with?
If you're new to microdosing, start with Neat- 50 mg (if you're sensitive or cautious) or Neat 100 mg (the standard starting point for most people). Both are pure single-ingredient formulas that give you a clean baseline to understand how your body responds before exploring the blended formulas.
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Are all Nuance products lab-tested?
Yes — every product in the Nuance lineup is independently third-party tested for potency and purity. Certificates of Analysis (COAs) are publicly available and linked on each individual product page. This includes the CBN isolate in Somnium, which has its own separate COA confirming 0% THC.
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What's the difference between pure formulas and blended formulas?
Pure formulas (Neat-, Neat, Neat+, Neat++) contain only P. cubensis and microcrystalline cellulose — they're designed for a clean baseline or for building up dose strength. Blended formulas (Vitality, Somnium, Bright, Dirty) combine P. cubensis with additional botanicals, adaptogens, or cannabinoids for specific wellness outcomes — brain health, sleep, mood, or physical performance.
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What is the Nuance Network?
Every Nuance purchase includes access to Nuance Network Groups — monthly 60-minute virtual sessions held on the third Sunday of each month at 10:00 AM Pacific. Led by an integration specialist, these sessions offer education, community connection, and professional peer support. It's included in the price of every product — no additional cost.
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How is shipping handled?
Nuance ships with a flat rate of $10 for shipping and handling. Every order includes a built-in carbon offset fee to counterbalance the emissions from shipping. Orders arrive in discreet packaging and appear as NUANCE WELLNESS on your credit card statement. Please double check your address to ensure prompt delivery (include apartment or unit number if applicable!!).
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Can I take more than one formula at a time?
Some people rotate formulas based on their needs — for example, using Vitality on workdays and Somnium on rest evenings. We recommend establishing your response to a single formula before combining or rotating. When in doubt, use the Find Your Formula tool on the website or reach out directly.
$10 flat-rate shipping · Carbon-offset included
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These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Testimonials reflect individual experiences and may not represent typical results. Consult a healthcare professional if you have health concerns. Do not replace prescribed medications without consulting your doctor.