Intentional MIcrodose Formulation
Stamet's Stack
Cognitive Support
Microdosing, upgraded. Brain health built in.
$45 30 capsules · $1.50/dose
Lab-tested for potency & purity
Vegan · Gluten-free
GMO-free
Carbon-offset shipping
Certificate of analysis available
whats inside + why it matters
Psilocybe cubensis
(Magic mushrooms)
100 mg per capsule
The same premium psilocybin mushroom at the heart of every Nuance formula. At 100 mg, it provides a gentle sub-perceptual foundation — supporting emotional balance, stress relief, and mental openness without overwhelming.
Hericium erinaceus
(Lion's Mane mushroom)
200 mg per capsule
Sourced from Far West Fungi. One of the most well-researched functional mushrooms for brain health — widely associated with support for memory, concentration, and nerve growth factor (NGF), a protein involved in the growth and maintenance of neurons. Paired with psilocybin, believed to amplify the neurogenic potential of the practice.
Niacin (Vitamin B3)
20 mg per capsule
Acts as a delivery enhancer in this stack — supporting increased blood flow and helping transport the other compounds more effectively throughout the body. A small but intentional addition that rounds out the synergy of the formula.
Note on niacin flush: Niacin can cause a temporary warm, tingly, or slightly flushed sensation on the skin — this is normal and typically passes within 20–60 minutes. If you're sensitive to it, an antihistamine may help ease the sensation.
why vitality 100 mg?
🧬
Neurogenesis Support
Lion's Mane is associated with NGF stimulation — supporting the growth and maintenance of neurons alongside psilocybin's neuroplasticity potential.
🎯
Cognitive Focus
Designed for mental clarity, concentration, and creative or analytical flow — more targeted than a pure psilocybin formula alone.
🔬
Independently Tested
Every batch third-party verified for potency and purity. COA publicly linked — full transparency on every ingredient at every dose level.
🤝
Community included
Monthly Nuance Network sessions with an integration specialist. Education, peer support, and professional guidance — built into the price.
What you may experience
A greater sense of mental clarity and sharpness on dose days — more focused and engaged
Enhanced ability to concentrate during creative, analytical, or deep work tasks
Emotional steadiness and a sense of groundedness that supports consistent daily function
Cumulative support for cognitive wellbeing that builds meaningfully over a sustained protocol
Effects are more nuanced than a single-ingredient product — journaling dose days is especially useful with this formula
Whos it for?
Those who want to pair the mood and emotional benefits of psilocybin with targeted brain health support
Knowledge workers, creatives, and high-performers seeking sustainable cognitive enhancement
People interested in the Stamets Stack who want a pre-formulated capsule with lab tested ingredients, rather than self-sourcing and measuring individual ingredients
Anyone building a long-term neurological wellness practice with psilocybin at its foundation
Those already comfortable with Neat 100 who want to add functional mushroom and nootropic support to their protocol
Product specs
P. cubensis per capsule
100 mg (Fruiting Bodies)
Lion's Mane per capsule
200 mg (Fruiting Bodies)
Niacin (B3) per capsule
20 mg (Powder)
Capsules per bottle
30 capsules
Suggested use
1–2 capsules, every 3 days
Capsule type
Vegan HPMC (size 00), preservative-free
Certifications
Vegan · GMO-free · Gluten-free
Testing
Nuance Network included with every purchase
Your purchase includes access to monthly 60-minute virtual group sessions led by an integration specialist. Third Sunday of each month, 10:00 AM Pacific. Community, education, and peer support — built into the price.
frequently asked questions
What is the Stamets Stack?
The Stamets Stack is a microdosing protocol developed by mycologist Paul Stamets that combines psilocybin mushrooms, Lion's Mane, and Niacin. The theory is that Lion's Mane stimulates nerve growth factor (NGF) to support neurogenesis, while Niacin aids delivery of the compounds throughout the body. Vitality is Nuance's ready-made, lab-tested version of this stack in a single capsule.
How is Vitality different from Neat 100?
Neat 100 is a pure single active ingredient formula — only P. cubensis. Vitality uses the same 100 mg psilocybin dose but adds 200 mg Lion's Mane and 20 mg Niacin for a synergistic, neuro-focused effect. If you want a clean baseline, start with Neat. If you want cognitive and neurological support layered in, Vitality is the next step.
What schedule should I follow?
We suggest the Fadiman protocol: 1 day on, 2 days off. Take 1–2 capsules every three days to prevent tolerance buildup and allow your nervous system time to integrate. Microdosing is highly individual — the protocol and time of administration can vary according to your lifestyle and daily requirements. With a multi-ingredient formula like Vitality, journaling your dose days is especially useful.
What is the niacin flush and should I be concerned?
The niacin flush is a temporary warm, tingly, or flushed sensation on the skin caused by increased blood flow — a well-known and harmless effect of Vitamin B3. It typically passes within 20–60 minutes. It is not an allergic reaction. If you're sensitive to it, taking an antihistamine beforehand can help ease the sensation. Most people find it diminishes with regular use.
Where does the Lion's Mane come from?
Nuance sources Lion's Mane from Far West Fungi, a trusted specialty mushroom cultivator. Ingredient sourcing transparency is part of how we maintain the quality and consistency you can expect from every bottle.
Is this product lab tested?
Yes. Every batch is independently tested for potency and purity. The Certificate of Analysis (COA) is publicly available — linked directly on the product page.
What will I see on my credit card statement?
Charges appear as NUANCE WELLNESS for your privacy.
customer review
Great product
"Very easy time ordering, great product and great support."
Ivan B. — Verified purchase, May 2025
Vitality
"It works great, as expected."
John — Verified purchase, Oct 2025
$10 flat-rate shipping · Carbon-offset included
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These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Testimonials reflect individual experiences and may not represent typical results. Consult a healthcare professional if you have health concerns. Do not replace prescribed medications without consulting your doctor.